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KMID : 1100220040030010037
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Dementia and Neurocognitive Disorders
2004 Volume.3 No. 1 p.37 ~ p.41
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Measurement of Anti-amyloid Beta Antibody in Serum of Alzheimer´s Disease Patients
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So Jung-On
Huh Ji-Yeon
Sim Hea-Jin
Kim Jong-Won
Na Duk-Lyul
Lee Phil-Hyu
Chung Sun-Ju
Park Mun-O
Joo In-Soo
Song Mi-Sook
Kim Young-Ho
Mook In-Hee
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Abstract
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Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that is rapidly increasing with the aging society, requiring a need for early diagnosis and prevention. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. AD is characterized by deposition of senile plaques and neurofibrillary tangles in the brain. Aβ peptide in senile plaques seems to play a central role in the neuropathology of AD. Several biochemical markers for AD are available, including reduced Aβ protein, a change in ratio between Aβ 40 and 42 and increased level of tau protein in the cerebrospinal fluid (CSF).
Methods: This study analyzes anti-Aβ antibody from serums of AD patients using the ELISA. The levels of anti-Aβ antibody from patients with idiopathic Parkinson’s disease or stroke and from normal control were compared to that of AD patients.
Results: Our results showed a significantly lower anti-Aβ antibody level in AD compared to those with other neurological diseases or control.
Conclusion: These data showed that the anti-Aβ antibody level in the serum may be used to diagnose the presence of AD.
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KEYWORD
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Alzheimer´s disease, Aβ peptide, Anti-Aβ autoantibody, Biomarker
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